Tingting Liu

2 papers in the library · 6 citations · publishing 2018-2025

Papers

Risk of manic switch and suicidal outcomes in bipolar depression treated with esketamine: A one-year retrospective cohort study of 2126 patients.

European Neuropsychopharmacology August 6, 2025 Tingting Liu, Jheng-Yan Wu, Po-Yu Huang et al. 6 citations

Esketamine, when added to a mood stabilizer, is associated with a lower risk of suicide-related events in adults with bipolar depression and does not increase the risk of manic switch. In a matched analysis of 2,126 patients, those receiving esketamine had a significantly lower hazard of suicide-related outcomes across intervals from 1–7 days (HR = 0.439) through 1–365 days (HR = 0.754). The risk of manic switch was also lower at 1–180 days (HR = 0.643) and 1–365 days (HR = 0.673). Suicide risk reduction was consistent across age, sex, and racial subgroups, while the lower manic switch risk was significant only in female patients at longer intervals.

DOI: 10.1016/j.euroneuro.2025.07.006 Medicine

Effects of Mindfulness-Based Stress Reduction on Depression in Adolescents and Young Adults: A Systematic Review and Meta-Analysis

Frontiers in Psychology June 21, 2018 Xinli Chi, Ai Bo, Tingting Liu et al.

Mindfulness-based stress reduction (MBSR) moderately reduces depressive symptoms in adolescents and young adults aged 12 to 25 years at the end of an intervention. A meta-analysis of 18 randomized controlled trials with 2,042 participants found a moderate effect (Hedges' g = −0.45) compared to control groups such as no treatment, treatment as usual, or active control. No statistically significant effects were observed at follow-up (Hedges' g = −0.24), likely due to insufficient statistical power. The average treatment effect may be influenced by the type of control condition, treatment duration, and participants' baseline depression levels.

DOI: 10.3389/fpsyg.2018.01034 Full text Mindfulness-based stress reduction Adolescents Young adults Randomized controlled trials +2