OBJECTIVE To evaluate the safety of esketamine in bipolar depression, focusing on suicide-related outcomes and manic switch across timeframe and demographic subgroups. METHODS This retrospective cohort study was conducted in May 2025 using data from the TriNetX global collaborative network. Adults with bipolar depression treated with esketamine plus a mood stabilizer were propensity...
PURPOSE The aim of this study was to investigate the feasibility and preliminary efficacy of a modified Mindfulness-Based Stress Reduction (MBSR) programme and Mindfulness-Based Cognitive Therapy (MBCT) programme for reducing the stress, depressive symptoms, and subjective burden of family caregivers of people with dementia (PWD). METHODS A prospective, parallel-group, randomized controlled...