3 papers in the library · 41 citations · publishing 2013-2019
The Science of Marijuana 2019 Leslie Iversen
Abstract Although there is currently only limited knowledge of how activation of the CB-1 receptor in brain leads to the many actions of THC, some general features of cannabinoid control mechanisms are emerging. This chapter discusses THC in relation to the inhibition of neurotransmitter release, cardiovascular effects, effects on motility and pain, and behavioral models including the “Billy...
The Science of Marijuana 2019 Leslie Iversen
Abstract The 19th century was a great era for plant chemistry. Many complex drug molecules, known as alkaloids, were isolated and identified from plants. This chapter discusses the history of the discovery of delta-9-tetrahyrocannabinol (THC) as the psychoactive substance in cannabis products and also the discovery of the cannabinoid receptors CB-1 and CB-2 in the body and brain. The mechanism...
Bioorganic & Medicinal Chemistry Letters June 1, 2013 Warunya Arunotayanun, Jeffrey W Dalley, Xi-Ping Huang et al. 41 citations
Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of...