Peripheral and Central Effects of THC
The Science of Marijuana 2019 DOI: 10.1093/oso/9780190846848.003.0003 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Cannabis |
| Key findings | Argues that although understanding of how CB-1 receptor activation in the brain produces THC's many actions is still limited, general features of cannabinoid control mechanisms are emerging. The chapter surveys THC's effects on neurotransmitter release, cardiovascular function, motility, pain, learning and memory, subjective intoxication, and animal behavioral models including the "Billy Martin tetrad." |
Abstract
Abstract Although there is currently only limited knowledge of how activation of the CB-1 receptor in brain leads to the many actions of THC, some general features of cannabinoid control mechanisms are emerging. This chapter discusses THC in relation to the inhibition of neurotransmitter release, cardiovascular effects, effects on motility and pain, and behavioral models including the “Billy Martin tetrad.” It also discusses human laboratory models, including studies on learning and memory. A key effect of cannabis is intoxication, and the subjective effects of cannabis are reported in detail. Finally, the value of animal behavior studies is discussed, including discriminative stimulus effects, effects on cognition, and anti-anxiety effects.
Comparable studies
Other narrative reviews on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Causal association between cannabis and psychosis: examination of the evidence | 2004 | Review | |
| Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. General (historical and pharmacological review) | 2018 | Review | |
| Psychiatric effects of cannabis | 2001 | Review | |
| Beyond THC: The New Generation of Cannabinoid Designer Drugs | 2011 | Review | |
| Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug | 2006 | Review |
Citations in the library
Cites 17
- Traditional marijuana, high‐potency cannabis and synthetic cannabinoids: increasing risk for psychosis World Psychiatry September 22, 2016
- Novel psychoactive substances of interest for psychiatry World Psychiatry February 1, 2016
- Cannabis use before age 15 and subsequent executive functioning The British Journal of Psychiatry May 31, 2011
- Acute and chronic effects of cannabinoids on effort-related decision-making and reward learning: an evaluation of the cannabis ‘amotivational’ hypotheses Psychopharmacology September 2, 2016
- Cannabis use and cognitive dysfunction Indian Journal of Psychiatry 2011
and 12 more in the library