Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents.
Psychopharmacology June 1, 2010 D Matthew Walentiny, Robert E Vann, Jonathan A Warner et al. 49 citations
Salvinorin A, the primary psychoactive derivative of the hallucinogenic herb Salvia divinorum, is a potent and highly selective kappa-opioid receptor (KOR) agonist. Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects. This study represents a systematic examination of this hypothesis. Salvinorin A was isolated from S. divinorum and was...