An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
Warunya Arunotayanun, Jeffrey W Dalley, Xi-Ping Huang, Vincent Setola, Ric Treble, Leslie Iversen, Bryan L. Roth, Simon Gibbons
Bioorganic & Medicinal Chemistry Letters June 1, 2013 DOI: 10.1016/j.bmcl.2013.03.066 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Topics | 5-MeO-DMT |
| Citations | 41 |
| Key findings | The structures and serotonin receptor binding profiles of alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine were determined. |
Abstract
Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine.