Heat increases MDMA-enhanced NAcc 5-HT and body temperature, but not MDMA self-administration.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology December 2010 Allison A Feduccia, Nundhun Kongovi, Christine L Duvauchelle
There is a concern that hot environments enhance adverse effects of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy"). In this study, long-term (4-weeks) daily MDMA self-administration sessions and an MDMA Challenge test were conducted with rats under normal and high thermal conditions (23° or 32°C). During MDMA self-administration sessions, activity and body temperature were increased by...