Denise F. Odear

2 papers in the library · 17 citations · publishing 1992-1994

Papers

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Metallation/reduction as a new approach to tritium labeling. The synthesis of [3H]ibogaine

Journal of Labelled Compounds and Radiopharmaceuticals April 1, 1994 Herbert H. Seltzman, Denise F. Odear, Christopher P. Laudeman et al. 7 citations

Abstract A new method is presented for the tritiation of aryl compounds with tritium gas which is conducted on the underivatized substrate. Combined directed ortho metallation and facile reduction of the carbonpotassium bond affords incorporation of tritium at high specific activity under mild conditions. The metallation/reduction method is demonstrated for the preparation of [ 3 H]ibogaine.

DOI: 10.1002/jlcr.2580340408 Tritium illumination Radiochemistry Substrate aquarium Reduction mathematics +6

A new approach to tritium labelling; the synthesis of [3H]ibogaine

Journal of the Chemical Society Chemical Communications 1992 Herbert H. Seltman, Denise F. Odear, F. Ivy Carroll et al. 10 citations

Tritium labelled ibogaine, for pharmacological studies as an anti-addiction treatment for cocaine abuse, is prepared by a new method for the tritiation of aryl compounds involving ortho metallation followed by facile reduction of the carbon–metal bond.

DOI: 10.1039/c39920001757 Tritium Labelling Radiochemistry Combinatorial chemistry +1