A new approach to tritium labelling; the synthesis of [3H]ibogaine
Herbert H. Seltman, Denise F. Odear, F. Ivy Carroll, Christopher D. Wyrick
Journal of the Chemical Society Chemical Communications 1992 DOI: 10.1039/c39920001757 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Method development paper Peer reviewed |
|---|---|
| Topics | Ibogaine |
| Keywords | Tritium Labelling Radiochemistry Combinatorial chemistry Biochemistry |
| Citations | 10 |
| Key points | A new method for tritiating aryl compounds via ortho metallation and reduction of the carbon–metal bond was developed to produce tritium labelled ibogaine for pharmacological studies. |
Abstract
Tritium labelled ibogaine, for pharmacological studies as an anti-addiction treatment for cocaine abuse, is prepared by a new method for the tritiation of aryl compounds involving ortho metallation followed by facile reduction of the carbon–metal bond.