Metallation/reduction as a new approach to tritium labeling. The synthesis of [3H]ibogaine
Herbert H. Seltzman, Denise F. Odear, Christopher P. Laudeman, F. Ivy Carroll, Christopher D. Wyrick
Journal of Labelled Compounds and Radiopharmaceuticals April 1, 1994 DOI: 10.1002/jlcr.2580340408 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Method development Peer reviewed |
|---|---|
| Topics | Ibogaine |
| Keywords | Tritium illumination Radiochemistry Substrate aquarium Reduction mathematics Chemical synthesis Combinatorial chemistry Aryl Organic chemistry Nuclear physics Biochemistry |
| Citations | 7 |
| Key points | A combined directed ortho metallation and reduction method enables tritiation of aryl compounds at high specific activity under mild conditions, as demonstrated for [3H]ibogaine. |
Abstract
Abstract A new method is presented for the tritiation of aryl compounds with tritium gas which is conducted on the underivatized substrate. Combined directed ortho metallation and facile reduction of the carbonpotassium bond affords incorporation of tritium at high specific activity under mild conditions. The metallation/reduction method is demonstrated for the preparation of [ 3 H]ibogaine.