THE UPTAKE AND DISTRIBUTION OF 14C-MESCALINE IN DIFFERENT ORGANS OF DEVELOPING RAT
Nandkumar S. Shah, Kanhaiya R. Shah, R.s. Lawrence, A.e. Neely
Drug Metabolism and Disposition March 1, 1975 DOI: 10.1016/s0090-9556(25)05702-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Rats of 1, 4, 8, 12, 20, and 60 days postnatal age |
| Intervention | 14-C-mescaline |
| Dose | 50 nCi/g |
| Duration | 30, 60, 90, and 120 min after injection |
| Topics | Mescaline |
| Keywords | Spleen Metabolite Kidney Physiology Distribution mathematics Endocrinology Pharmacology Hallucinogen |
| Citations | 6 |
| Key findings | Mescaline uptake is highest in the organs of younger rats, and the blood-brain barrier for mescaline develops gradually with age but is not completely impermeable in adults. |
Abstract
Rats of 1,4,8,12,20, and 60 days postnatal age were injected ip with 14-C-mescaline (50 nCi/g). The levels of mescaline and its deaminated metabolite, 3,4,5-trimethoxyphenylacetic acid, were examined in the brain, liver, heart, spleen, lung, and kidney at 30, 60, 90, and 120 min. Mescaline was rapidly taken up by all the organs examined. In general, the organs of younger rats accumulated much larger amounts than those of adult animals. Brain concentrated the lowest amounts in comparison with other tissues. In the brain, the uptake was the highest in 1-day-old rats and decreased with age. The disappearance of mescaline in various organs was comparatively slower in younger animals than in 20-day or older rats. Rats immediately after birth and uptake was the highest in 1-day-old rats and decreased with age. The disappearance of mescaline in various organs was comparatively slower in younger animals than in 20-day or older rats. Rats immediately after birth and up to 20 days of age metabolized mescaline less efficiently than adults. From the data, it appears that the blood-brain barrier for mescaline develops gradually with age but is not completely impermeable in adults.