THE UPTAKE AND DISTRIBUTION OF 14C-MESCALINE IN DIFFERENT ORGANS OF DEVELOPING RAT
Nandkumar S. Shah, Kanhaiya R. Shah, R.s. Lawrence, A.e. Neely
Drug Metabolism and Disposition March 1, 1975 DOI: 10.1016/s0090-9556(25)05702-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Rats of 1, 4, 8, 12, 20, and 60 days postnatal age |
| Intervention | 14-C-mescaline |
| Dose | 50 nCi/g |
| Duration | 30, 60, 90, and 120 min after injection |
| Topics | Mescaline |
| Keywords | Spleen Metabolite Kidney Physiology Distribution mathematics Endocrinology Pharmacology Hallucinogen |
| Citations | 6 |
| Key findings | Mescaline uptake is highest in the organs of younger rats, and the blood-brain barrier for mescaline develops gradually with age but is not completely impermeable in adults. |
Abstract
Rats of 1,4,8,12,20, and 60 days postnatal age were injected ip with 14-C-mescaline (50 nCi/g). The levels of mescaline and its deaminated metabolite, 3,4,5-trimethoxyphenylacetic acid, were examined in the brain, liver, heart, spleen, lung, and kidney at 30, 60, 90, and 120 min. Mescaline was rapidly taken up by all the organs examined. In general, the organs of younger rats accumulated much larger amounts than those of adult animals. Brain concentrated the lowest amounts in comparison with other tissues. In the brain, the uptake was the highest in 1-day-old rats and decreased with age. The disappearance of mescaline in various organs was comparatively slower in younger animals than in 20-day or older rats. Rats immediately after birth and uptake was the highest in 1-day-old rats and decreased with age. The disappearance of mescaline in various organs was comparatively slower in younger animals than in 20-day or older rats. Rats immediately after birth and up to 20 days of age metabolized mescaline less efficiently than adults. From the data, it appears that the blood-brain barrier for mescaline develops gradually with age but is not completely impermeable in adults.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |
Citations in the library
Cited by 2
- Regional localization of [14C]mescaline in rabbit brain after intraventricular administration Neurochemical Research June 1, 1977
- Behavioral effects and metabolic fate of N,N-dimethyltryptamine in mice pretreated with beta-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), improniazid and chlorpromazine. Pharmacology, Biochemistry, and Behavior April 1978