Der Nervenarzt
May 1, 2024
Bernhard T Baune, Sarah E Fromme, Maximilian Kiebs et al.
1 citation
Treatment-resistant depression (TRD) is a complex disorder. Although no standardized definition has been established to date, there are promising and well-established treatment options for the condition. Looking at the current pharmacological and neuromodulatory strategies, there is an urgent need for fast-acting and well-tolerated treatment options. The search for new mechanisms of action goes...
Neuroscience of Consciousness
2021
Mirko Lehmann, Claudia Neumann, Sven Wasserthal et al.
Only little research has been conducted on the pharmacological underpinnings of metacognition. Here, we tested the modulatory effects of a single intravenous dose (100 ng/ml) of the N-methyl-D-aspartate-glutamate-receptor antagonist ketamine, a compound known to induce altered states of consciousness, on metacognition and its neural correlates. Fifty-three young, healthy adults completed two...
Journal of Psychiatry and Neuroscience
February 26, 2020
Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al.
14 citations
Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between...
Kaeli Zimmermann, Keith M. Kendrick, Dirk Scheele et al.
preprint
ABSTRACT Public perception of cannabis as relatively harmless, alongside claimed medical benefits, have led to moves towards its legalization. Yet, long-term consequences of cannabis dependence, and whether they differ qualitatively from other drugs, are still poorly understood. A key feature of addictive drugs is that chronic use leads to adaptations in reward processing, blunting responsivity...