Journal of Psychiatry and Neuroscience
February 26, 2020
Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al.
14 citations
Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between...
bioRxiv (Cold Spring Harbor Laboratory)
September 29, 2018
Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al.
1 citation
preprint
Abstract Background Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations...
Human Brain Mapping
September 12, 2018
Feng Zhou, Kaeli Zimmermann, Fei Xin et al.
80 citations
The transition from voluntary to addictive behavior is characterized by a loss of regulatory control in favor of reward driven behavior. Animal models indicate that this process is neurally underpinned by a shift in ventral-dorsal striatal control of behavior; however, this shift has not been directly examined in humans. The present resting state functional magnetic resonance imaging (fMRI)...
Psychopharmacology
March 2018
Kaeli Zimmermann, Shuxia Yao, Marcel Heinz et al.
Intact cognitive and emotional functioning is vital for the long-term success of addiction treatment strategies. Accumulating evidence suggests an association between chronic marijuana use and lasting alterations in cognitive brain function. Despite initial evidence for altered emotion processing in dependent marijuana users after short abstinence periods, adaptations in the domain of emotion...
Kaeli Zimmermann, Keith M. Kendrick, Dirk Scheele et al.
preprint
ABSTRACT Public perception of cannabis as relatively harmless, alongside claimed medical benefits, have led to moves towards its legalization. Yet, long-term consequences of cannabis dependence, and whether they differ qualitatively from other drugs, are still poorly understood. A key feature of addictive drugs is that chronic use leads to adaptations in reward processing, blunting responsivity...