4 papers in the library · 111 citations · publishing 2012-2026
Biomed Pharmacother March 19, 2026 Giulia Costa, Marcello Serra, Riccardo Maccioni et al. correction
Corrigendum "Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice." [Biomed. Pharmacother. 161 (2023) 114475].
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie May 1, 2023 Giulia Costa, Marcello Serra, Riccardo Maccioni et al. 13 citations
Withania somnifera (WS) is utilized in Ayurvedic medicine owing to its central and peripheral beneficial properties. Several studies have accrued indicating that the recreational amphetamine-related drug (+/-)- 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) targets the nigrostriatal dopaminergic system in mice, inducing neurodegeneration and gliosis, causing acute hyperthermia and cognitive...
Movement Disorders September 20, 2013 Giulia Costa, Lucia Frau, Jadwiga Wardas et al. 52 citations
ABSTRACT Clinical observations report a greater propensity to develop Parkinson's disease (PD) in amphetamine users. 3,4‐Methylenedioxymethamphetamine (MDMA; “ecstasy”) is an amphetamine‐related drug that is largely consumed by adolescents and young adults, which may have neuroinflammatory and neurotoxic effects. Here, the objective was to evaluate in mice whether consumption of MDMA during...
Journal of Neurochemistry October 20, 2012 Lucia Frau, Nicola Simola, Antonio Plumitallo et al. 46 citations
Abstract Evidence is accumulating to suggest that 3,4‐methylenedioxymethamphetamine ( MDMA ) has neurotoxic and neuroinflammatory properties. MDMA is composed of two enantiomers with different biological activities. In this study, we evaluated the in vivo effects of S(+)‐ MDMA , R(−)‐ MDMA , and S(+)‐ MDMA in combination with R(−)‐ MDMA on microglial and astroglial activation compared with...