Antagonism of Adenosine A 1 or A 2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions
Journal of Caffeine Research June 1, 2014 Amit Khairnar, Lucia Frau, Antonio Plumitallo et al.
Background: Previous studies by our group have demonstrated that caffeine, an antagonist of adenosine A 1 and A 2A receptors, amplifies the glial activation induced by 3,4-methylendioxymethamphetamine (MDMA, “ecstasy”) in mice. To elucidate the mechanisms underlying this effect, the present study evaluated whether selective antagonists for the A 1 or the A 2A adenosine receptor had any...