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Yosuke Demizu

2 papers in the library · 3 citations · publishing 2022-2024

Papers

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Structural analysis of an lysergic acid diethylamide (LSD) analogue N-methyl-N-isopropyllysergamide (MiPLA): Insights from Rotamers in NMR spectra.

Drug Testing and Analysis June 1, 2024 Takuji Shoda, Genichiro Tsuji, Maiko Kawamura et al. 1 citation

Lysergic acid diethylamide (LSD) is a hallucinogenic compound that binds to and activates the serotonin 2A receptor and is classified as a controlled narcotic in Japan. Recently, MiPLA, an N-methyl-N-isopropyl derivative of LSD, has been detected in paper-sheet products in several countries. This study focuses on the synthesis of MiPLA and includes a comprehensive analysis involving structural...

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors.

Journal of Pharmacological Sciences December 1, 2022 Tomohiko Irie, Yuta Yanase, Yosuke Demizu et al. 2 citations

N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine). The recreational methoxetamine use can cause several toxicities and methoxetamine-related deaths have also been reported. Therefore, it has been banned in...