Yuta Yanase

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors.

Journal of Pharmacological Sciences December 1, 2022 Tomohiko Irie, Yuta Yanase, Yosuke Demizu et al. 2 citations

N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine). The recreational methoxetamine use can cause several toxicities and methoxetamine-related deaths have also been reported. Therefore, it has been banned in...