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David Spiegel

5 papers in the library · 288 citations · publishing 2013-2026

Papers

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A fully remote randomized controlled trial of an ultra-brief digital meditation intervention reduces internalizing symptoms

medRxiv Preprint Server April 19, 2026 Cameron C. Glick, Saad Pirzada, Shaun K.l. Quah et al. preprint

Background Scalable, low-burden behavioral interventions are needed to address rising subclinical mental health symptoms. However, few randomized controlled trials have evaluated ultra-brief, remotely delivered, meditation using multimodal outcome assessment under real-world conditions.

Accelerated recovery using magnesium ibogaine: characterizing the subjective experience of its rapid healing from neuropsychiatric disorders.

npj Mental Health Research January 31, 2026 Clayton Olash, Derrick Matthew Buchanan, Randi Brown et al. 1 citation

Magnesium-ibogaine, a formulation combining ibogaine with pre- and post-treatment magnesium, was recently found to yield rapid clinical improvements in U.S. Special Operations veterans with TBI and PTSD. Yet, its therapeutic phenomenology during such healing is unknown. We analyzed post-session narratives from 30 male veterans who, after a single open-label magnesium-ibogaine treatment,...

Brief structured respiration practices enhance mood and reduce physiological arousal

Cell Reports Medicine 2023 Melis Yilmaz Balban, Eric Neri, Manuela M. Kogon et al. 261 citations

Controlled breathwork practices have emerged as potential tools for stress management and well-being. Here, we report a remote, randomized, controlled study (NCT05304000) of three different daily 5-min breathwork exercises compared with an equivalent period of mindfulness meditation over 1 month. The breathing conditions are (1) cyclic sighing, which emphasizes prolonged exhalations; (2) box...

Association between Anterior Cingulate Neurochemical Concentration and Individual Differences in Hypnotizability

Cerebral Cortex December 16, 2019 Danielle D. DeSouza, Katy H. Stimpson, Laima Baltusis et al. 26 citations

Hypnosis is the oldest form of Western psychotherapy and a powerful evidence-based treatment for numerous disorders. Hypnotizability is variable between individuals; however, it is a stable trait throughout adulthood, suggesting that neurophysiological factors may underlie hypnotic responsiveness. One brain region of particular interest in functional neuroimaging studies of hypnotizability is...

Tranceformations: hypnosis in brain and body.

Depression and Anxiety April 1, 2013 David Spiegel

In this review, the role of hypnosis and related psychotherapeutic techniques are discussed in relation to the anxiety disorders. In particular, anxiety is addressed as a special form of mind/body problem involving reverberating interaction between mental and physical distress. The history of hypnosis as a therapeutic discipline is reviewed, after which neurobiological evidence of the effect of...