Philosophy and the Mind Sciences
May 27, 2026
Edmundo Lopez-Sola, Roser Sanchez-Todo, Jakub Vohryzek et al.
1 citation
The phenomenon of “pure awareness”, central to many contemplative traditions, has recently attracted scientific interest for its relevance to the study of consciousness. In this paper, we investigate pure awareness through the algorithmic agent model, a computational framework with roots in algorithmic information theory. This framework proposes that agents build compressive models of the...
bioRxiv (Cold Spring Harbor Laboratory)
March 19, 2025
Giulio Ruffini, Edmundo Lopez-Sola, Raul P. Aristides et al.
8 citations
preprint
Abstract Predictive coding frameworks suggest that neural computations rely on hierarchical error minimization, where sensory signals are evaluated against internal model predictions. However, the neural implementation of this inference process remains unclear. We propose that cross-frequency coupling (CFC) furnishes a fundamental mechanism for this form of inference. We first demonstrate that...
bioRxiv (Cold Spring Harbor Laboratory)
December 16, 2024
Jan C. Gendra, Edmundo Lopez-Sola, Francesca Castaldo et al.
7 citations
preprint
Abstract Classical serotonergic psychedelics show promise in addressing neurodegenerative disorders such as Alzheimer’s disease by modulating pathological brain dynamics. However, the precise neurobiological mechanisms underlying their effects remain elusive. This study introduces a personalized whole-brain model built upon a laminar neural mass framework to elucidate these effects. Using...
Entropy
November 6, 2024
Giulio Ruffini, Francesca Castaldo, Edmundo Lopez-Sola et al.
10 citations
Major Depressive Disorder (MDD) is a complex, heterogeneous condition affecting millions worldwide. Computational neuropsychiatry offers potential breakthroughs through the mechanistic modeling of this disorder. Using the Kolmogorov theory (KT) of consciousness, we developed a foundational model where algorithmic agents interact with the world to maximize an Objective Function evaluating...
Entropy
January 22, 2024
Giulio Ruffini, Edmundo Lopez-Sola, Jakub Vohryzek et al.
15 citations
We explore the intersection of neural dynamics and the effects of psychedelics in light of distinct timescales in a framework integrating concepts from dynamics, complexity, and plasticity. We call this framework neural geometrodynamics for its parallels with general relativity’s description of the interplay of spacetime and matter. The geometry of trajectories within the dynamical landscape of...