Restoring Oscillatory Dynamics in Alzheimer’s Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects
bioRxiv (Cold Spring Harbor Laboratory) December 16, 2024 Jan C. Gendra, Edmundo Lopez-Sola, Francesca Castaldo et al. 7 citations preprint
Abstract Classical serotonergic psychedelics show promise in addressing neurodegenerative disorders such as Alzheimer’s disease by modulating pathological brain dynamics. However, the precise neurobiological mechanisms underlying their effects remain elusive. This study introduces a personalized whole-brain model built upon a laminar neural mass framework to elucidate these effects. Using...