Human Brain Mapping
December 6, 2019
Anna Forsyth, Rebecca McMillan, Doug Campbell et al.
19 citations
The pharmacological modulation of functional connectivity in the brain may underlie therapeutic efficacy for several neurological and psychiatric disorders. Functional magnetic resonance imaging (fMRI) provides a noninvasive method of assessing this modulation, however, the indirect nature of the blood-oxygen level dependent signal restricts the discrimination of neural from physiological...
British Journal of Anaesthesia
February 4, 2018
Jamie Sleigh, Catherine E. Warnaby, Irene Tracey
35 citations
Selfhood is linked to brain processes that enable the experience of a person as a distinct entity, capable of agency. This framework naturally incorporates a continuum of both non-conscious and conscious self-related information processing, and includes a hierarchy of components, such as awareness of existence (core self), embodied self (sentience), executive self (agency/volition), and various...
Journal of visualized experiments : JoVE
January 13, 2018
Andria Pelentritou, Levin Kuhlmann, John Cormack et al.
Anesthesia arguably provides one of the only systematic ways to study the neural correlates of global consciousness/unconsciousness. However to date most neuroimaging or neurophysiological investigations in humans have been confined to the study of γ-Amino-Butyric-Acid-(GABA)-receptor-agonist-based anesthetics, while the effects of dissociative...
Trends in Anaesthesia and Critical Care
March 22, 2014
Jamie Sleigh, Martyn Harvey, Logan J. Voss et al.
441 citations
Ketamine has been in clinical use for over half a century, yet its precise mechanisms of action remain mysterious for the large part. Its hypnotic effects appear to be largely mediated by blockade of NMDA and HCN1 receptors, but cholinergic, aminergic, and opioid systems appear to play both a positive and negative modulatory role in both sedation and analgesia. Ketamine's effects in chronic...
Anesthesiology
February 7, 2012
Robert D. Sanders, Giulio Tononi, Steven Laureys et al.
478 citations
Consciousness is subjective experience. During both sleep and anesthesia, consciousness is common, evidenced by dreaming. A defining feature of dreaming is that, while conscious, we do not experience our environment; we are disconnected. Besides inducing behavioral unresponsiveness, a key goal of anesthesia is to prevent the experience of surgery (connected consciousness), by inducing either...
Anesthesiology
September 1, 2009
Kate Leslie, Jamie Sleigh, Michael J Paech et al.
Dream recall is reportedly more common after propofol than after volatile anesthesia, but this may be due to delayed emergence or more amnesia after longer-acting volatiles. The electroencephalographic signs of dreaming during anesthesia and the differences between propofol and desflurane also are unknown. The authors therefore compared dream recall after propofol- or desflurane-maintained...