Human Brain Mapping
March 19, 2021
Andrea I. Luppi, Daniel Golkowski, Andreas Ranft et al.
72 citations
Abstract The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional...
Neuroimage
February 15, 2021
Andrea I. Luppi, Robin Carhart-Harris, Leor Roseman et al.
186 citations
Investigating changes in brain function induced by mind-altering substances such as LSD is a powerful method for interrogating and understanding how mind interfaces with brain, by connecting novel psychological phenomena with their neurobiological correlates. LSD is known to increase measures of brain complexity, potentially reflecting a neurobiological correlate of the especially rich...
Neuroimage
June 30, 2020
Thomas F. Varley, Robin Carhart-Harris, Leor Roseman et al.
91 citations
Psychedelic drugs, such as psilocybin and LSD, represent unique tools for researchers investigating the neural origins of consciousness. Currently, the most compelling theories of how psychedelics exert their effects is by increasing the complexity of brain activity and moving the system towards a critical point between order and disorder, creating more dynamic and complex patterns of neural...
Scientific Reports
January 23, 2020
Thomas F. Varley, Andrea I. Luppi, Ioannis Pappas et al.
86 citations
The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and topological domains, testing them on functional MRI BOLD signal data obtained...
bioRxiv (Cold Spring Harbor Laboratory)
January 11, 2019
Tf. Varley, Robin Carhart-Harris, Leor Roseman et al.
8 citations
preprint
Abstract Psychedelic drugs, such as psilocybin and LSD, represent unique tools for researchers in-vestigating the neural origins of consciousness. Currently, the most compelling theories of how psychedelics exert their effects is by increasing the complexity of brain activity and moving the system towards a critical point between order and disorder, creating more dynamic and complex patterns of...
PLoS One
June 29, 2012
Laura Moreno-López, Emmanuel A. Stamatakis, María José Fernández-serrano et al.
73 citations
INTRODUCTION: Functional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings from such studies may be relevant to implement specific interventions for treatment. The aim of this study was to examine the association between resting-state regional...
Dian Lu, Adapa Ram, Robin Carhart-Harris et al.
Abstract Large-scale functional connectivity (FC) networks are typically treated as discrete neuroanatomical entities, yet their organisation in regions where multiple systems converge remains poorly understood. Here we investigate the posterior precuneus (PCu)—a key hub of the default mode network (DMN) situated at the interface with the frontoparietal control network (FPCN)—using a...