Science Advances
June 14, 2023
Leor Roseman, Christopher Timmermann, Daniel Golkowski et al.
65 citations
To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution of 19 neurotransmitter receptors and transporters...
Communications Biology
January 28, 2023
Andrea I. Luppi, Jakub Vohryzek, Morten L. Kringelbach et al.
98 citations
A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations of consciousness into distributed patterns of structure-function dependence across scales: the harmonic modes of the human structural connectome. We show that...
bioRxiv (Cold Spring Harbor Laboratory)
July 13, 2022
Andrea I. Luppi, Justine Y. Hansen, Ram Adapa et al.
5 citations
preprint
Abstract To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically-induced macroscale functional reorganisation, by relating the regional distribution of 19 neurotransmitter receptors and...
Proceedings of the National Academy of Sciences of the United States of America
July 23, 2021
Lennart R.b. Spindler, Andrea I. Luppi, Ram Adapa et al.
Significance Understanding the neural bases of consciousness is of basic scientific and clinical importance. Human neuroimaging has established that a network of interconnected brain regions known as the default mode network disintegrates in anesthesia and after brain damage that causes disorders of consciousness. However, the neurochemical underpinnings of this network change remain largely...
Human Brain Mapping
2017
Deniz Vatansever, Anne E. Manktelow, Barbara J. Sahakian et al.
AbstractInitially identified during no‐task, baseline conditions, it has now been suggested that the default mode network (DMN) engages during a variety of working memory paradigms through its flexible interactions with other large‐scale brain networks. Nevertheless, its contribution to whole‐brain connectivity dynamics across increasing working memory load has not been explicitly assessed. The...
Neuroimage
July 26, 2015
Deniz Vatansever, D.K. Menon, Anne E. Manktelow et al.
157 citations
Initially described as task-induced deactivations during goal-directed paradigms of high attentional load, the unresolved functionality of default mode regions has long been assumed to interfere with task performance. However, recent evidence suggests a potential default mode network involvement in fulfilling cognitive demands. We tested this hypothesis in a finger opposition paradigm with task...