Phytochemical analysis : PCA
August 1, 2024
Joana Gonçalves, Tiago Rosado, Mário Barroso et al.
2 citations
Ayahuasca is a psychoactive drink originally consumed by indigenous people of the Amazon. The lack of regulation of this drink leads to uncontrolled consumption, and it is often consumed in religious contexts. The aim of this work is to compare three miniaturised extraction techniques for extracting the main ayahuasca compounds from beverages. Three sample pretreatment techniques were evaluated...
Natural Product Research
July 4, 2024
Joana Gonçalves, José Francisco Cascalheira, Patrícia Valentão et al.
Ayahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,N-dimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca...
Pharmaceuticals (Basel, Switzerland)
June 2, 2024
Joana Gonçalves, Mariana Feijó, Sílvia Socorro et al.
The psychedelic beverage ayahuasca is originally obtained by Banisteriopsis caapi (B. caapi) (BC) and Psychotria viridis (P. viridis) (PV). However, sometimes these plant species are replaced by others that mimic the original effects, such as Mimosa hostilis (M. hostilis) (MH) and Peganum harmala (P. harmala) (PH). Its worldwide consumption and the number of studies on its potential therapeutic...
Plants (Basel, Switzerland)
July 7, 2023
Joana Gonçalves, Ângelo Luís, Eugenia Gallardo et al.
16 citations
Traditional therapies, resorting to the use of plants, have acquired a great demand over the years, both for economic reasons and the preference for natural treatments. Some studies suggest that ayahuasca may have beneficial properties in treating some physical and psychological imbalances. Thus, we carried out a systematic review of studies published up to December 2022, where these themes...
Molecules (Basel, Switzerland)
September 6, 2022
Joana Gonçalves, Ângelo Luís, Eugenia Gallardo et al.
5 citations
Ayahuasca is an Amazonian drink, which contains β-carboline alkaloids and N,N-dimethyltryptamine. The aim of this study was to evaluate the healing potential of decoctions of a commercial mixture, four individual plants and four mixtures of two plants used in the ayahuasca preparation. Thus, the cytotoxic potential of the samples was evaluated and a wound-healing assay was performed with a NHDF...
Molecules
September 13, 2021
Joana Gonçalves, Miguel Castilho, Tiago Rosado et al.
9 citations
Ayahuasca is a psychoactive beverage that contains the psychoactive compound N,N-dimethyltryptamine and β-carboline alkaloids. This study aims at determining in vitro the bioavailability and bioaccessibility of the main compounds present in decoctions of four individual plants, in a commercial mixture and in four mixtures of two individual plants used in the preparation of Ayahuasca. The...
Molecules (Basel, Switzerland)
March 5, 2021
Joana Gonçalves, Ângelo Luís, Eugenia Gallardo et al.
39 citations
The consumption of new psychoactive substances (NPSs) has been increasing, and this problem affects several countries worldwide. There is a class of NPSs of natural origin, consisting of plants and fungi, which have a wide range of alkaloids, responsible for causing relaxing, stimulating or hallucinogenic effects. The consumption of some of these substances is prompted by religious beliefs and...
Antibiotics
October 24, 2020
Joana Gonçalves, Ângelo Luís, Ana Gradillas et al.
25 citations
Ayahuasca is a psychoactive beverage, originally consumed by indigenous Amazon tribes, of which consumption has been increasing worldwide. The aim of this study was to evaluate the phytochemical profile, as well as the antioxidant, anti-inflammatory and antimicrobial properties of decoctions of four individual plants, a commercial mixture and four mixtures of two individual plants used in the...
Biomedicines
September 5, 2020
Ana Sofia Vargas, Ângelo Luís, Mário Barroso et al.
121 citations
Psilocybin is a naturally occurring tryptamine known for its psychedelic properties. Recent research indicates that psilocybin may constitute a valid approach to treat depression and anxiety associated to life-threatening diseases. The aim of this work was to perform a systematic review with meta-analysis of clinical trials to assess the therapeutic effects and safety of psilocybin on those...