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Adam M Lee

2 papers in the library · 9 citations · publishing 2018-2024

Papers

Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD.

Molecular Neurobiology November 1, 2024 Adam M Lee, Paul Thuras, Joshua Baller et al. 9 citations

Meditation-based therapies such as mindfulness-based stress reduction and Transcendental Meditation can reduce PTSD symptoms in veterans. In 72 veterans with PTSD, those with the 5HTTLPR LALA high expression genotype of the serotonin transporter gene who had experienced early life trauma showed greater symptom improvement. Additionally, changes in DNA methylation at nine specific sites in the FKBP5 gene from before to after treatment were linked to greater symptom improvement, with an odds ratio of 2.8. These findings suggest that genetic and epigenetic markers in the SLC6A4 and FKBP5 genes may be important for understanding treatment mechanisms and predicting symptom improvement.

DOI: 10.1007/s12035-024-04096-6 (opens in new tab) Full text (opens in new tab) Mindfulness-based stress reduction Posttraumatic stress disorder Serotonin transporter slc6a4 Transcendental meditation

Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder.

Frontiers in Psychiatry January 1, 2018 Jeffrey R Bishop, Adam M Lee, Lauren J Mills et al.

Veterans with PTSD who responded to Mindfulness Based Stress Reduction (MBSR) showed decreased methylation in a specific region of the FKBP5 gene after treatment, while non-responders showed increased methylation. The change occurred in a glucocorticoid response element, suggesting meditation may affect stress-related molecular pathways. No baseline methylation differences were found between responders and non-responders. These preliminary results from 22 veterans indicate FKBP5 DNA methylation could be a biomarker for MBSR treatment response in PTSD, but validation in larger studies is needed.

DOI: 10.3389/fpsyt.2018.00418 (opens in new tab) Full text (opens in new tab) Mbsr PTSD Meditation Dna methylation +4