Journal of Neurochemistry
January 29, 2026
Paola Andrea Caro Aponte, Edison Huertas Montoya, Ítalo Odone Mazali et al.
Currently, no effective treatment exists for injuries at the interface between the CNS/PNS, largely due to their complex pathophysiology and the limited efficacy of single-target therapies. To address this challenge, we investigated a novel combinatorial therapeutic strategy integrating surgical VRR with fibrin sealant biopolymer (FSB) and DMT in a rat model of ventral root avulsion VRA. DMT...
The Plant journal : for cell and molecular biology
July 1, 2025
Taynara Simão Matos, Camila Dias Lourenço Dos Santos, Luís Fernando Tófoli et al.
Psychotria viridis Ruiz & Pav. has gained significant attention due to its role in the preparation of ayahuasca. This study aimed to improve the understanding of the specialized metabolite profile in P. viridis leaves and to evaluate how growing conditions and seasonality impact this composition. The specimens were grown either in the open field or in the shaded environment of rubber tree...
Journal of Psychoactive Drugs
October 29, 2024
Taynara Simão Matos, Flávia Da Silva Zandonadi, Alex Aparecido Rosini Silva et al.
Ayahuasca is a brew traditionally prepared with a mixture of Psychotria viridis leaves and Banisteriopsis caapi vine and has demonstrated therapeutic properties for depression. Knowledge of the brew composition is important to improve the therapeutic potential and decrease side effects if ayahuasca becomes an option for refractory depression treatment. Ultra-high performance liquid...
Analytical and Bioanalytical Chemistry
July 1, 2023
Flávia S Zandonadi, Alex Ap Rosini Silva, Aline A S Melo et al.
9 citations
Emerging insights from metabolomic-based studies of major depression disorder (MDD) are mainly related to biochemical processes such as energy or oxidative stress, in addition to neurotransmission linked to specific metabolite intermediates. Hub metabolites represent nodes in the biochemical network playing a critical role in integrating the information flow in cells between metabolism and...
Behavioural Brain Research
April 1, 2022
Dimitri Daldegan-Bueno, Vanessa Manchim Favaro, Paulo Rogério Morais et al.
10 citations
Considering the long-lasting effects of ayahuasca on the brain and emotional processing, the objective of this study was to evaluate the behavioural and neurobiological effects of repeated ayahuasca administration in an animal model of exploratory behaviour related to novel-environment anxiety. Male Wistar rats received water, 120, 240, 480 or 3600 mg/kg of resuspended freeze-dried ayahuasca by...
Journal of Psychoactive Drugs
September 17, 2021
Dimitri Daldegan-Bueno, Vanessa Manchim Favaro, Luís Fernando Tófoli et al.
6 citations
Ayahuasca is a psychoactive brew from the decoction of different Amazonian plants, traditionally used in several cultures, religions, and rituals. Scientific studies with ayahuasca are rapidly increasing due to its subjective effects and therapeutic potential. Although ayahuasca is traditionally used in its liquid presentation, lyophilized (freeze-dried) ayahuasca is often used in scientific...
Journal of Psychoactive Drugs
September 8, 2020
Helle Kaasik, Rita C. Z. Souza, Flávia Da Silva Zandonadi et al.
54 citations
Traditional ayahuasca can be defined as a brew made from Amazonian vine Banisteriopsis caapi and Amazonian admixture plants. Ayahuasca is used by indigenous groups in Amazonia, as a sacrament in syncretic Brazilian religions, and in healing and spiritual ceremonies internationally. The study aimed to determine concentrations of the main bio- and psychoactive components of ayahuasca used in...
Biological Trace Element Research
June 5, 2020
Ivanilce Cristina Guimarães, Luís Fernando Tófoli, Alessandra Sussulini
7 citations
The consumption of ayahuasca, a brew prepared from the decoction of two Amazon plants, has increased worldwide in the last decades. This fact raised questions about the safety in its oral administration. In this sense, information concerning the chemical composition of ayahuasca is essential to find a comprehensive reply. Therefore, the aim of this study consisted of determining the elemental...
Journal of Chromatography B
June 8, 2019
Rita C. Z. Souza, Flávia Da Silva Zandonadi, Donizete P. Freitas et al.
42 citations
Ayahuasca is a brew prepared from the water decoction of two Amazonian plants, which is legally used for religious, cultural or therapeutic activities. The potential use of ayahuasca as a natural or phytotherapeutic drug is directly linked to the action of its active compounds and their connection with the therapeutic efficacy of the beverage. In this context, the aim of the present study was...