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Jim Gilligan

5 papers in the library · 32 citations · publishing 2023-2025

Papers

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Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex

Translational Psychiatry March 25, 2025 Brian H Silverstein, Nicholas Kolbman, Amanda Nelson et al. 8 citations

Psilocybin produces an altered state of consciousness in humans and is associated with complex spatiotemporal changes in cortical networks. Given the emphasis on rodent models for mechanistic studies, there is a need for characterization of the effect of psilocybin on cortex-wide network dynamics. Previous electroencephalographic studies of psychedelics in rodents have primarily used sparse...

Psilocybin induces dose-dependent changes in functional network organization in rat cortex

bioRxiv (Cold Spring Harbor Laboratory) February 12, 2024 Brian H Silverstein, Nicholas Kolbman, Amanda Nelson et al. 3 citations preprint

Abstract Psilocybin produces an altered state of consciousness in humans and is associated with complex spatiotemporal changes in brain networks. Given the emphasis on rodent models for mechanistic studies, there is a need for characterization of the effect of psilocybin on brain-wide network dynamics. Previous rodent studies of psychedelics, using electroencephalogram, have primarily been done...

Intravenous psilocybin attenuates mechanical hypersensitivity in a rat model of chronic pain

Current Biology December 1, 2023 Nicholas Kolbman, Tiecheng Liu, Peter R. Guzzo et al. 21 citations

There is a renewed interest in psychedelic drugs as potential therapeutic agents for the treatment of psychiatric disorders. In particular, psilocybin has shown promise for the treatment of refractory depression1 and major depressive disorder2, and has also been explored as a treatment for tobacco and alcohol abuse3,4. However, despite suggestive evidence5,6, there has been no systematic study...

DOI: 10.1016/j.cub.2023.10.016 (opens in new tab) Psychedelics Psilocybin therapy Pain management Medical research +1

Intravenous psilocybin administration attenuates mechanical hypersensitivity in a rat model of chronic pain

bioRxiv (Cold Spring Harbor Laboratory) August 28, 2023 Nicholas Kolbman, Tiecheng Liu, Peter R. Guzzo et al. preprint

Abstract There is a renewed interest in the therapeutic potential of psychedelics, including psilocybin, in treating mental health disorders. However, there are no data on the efficacy of psilocybin in alleviating chronic pain. In this study, we investigated the effect of psilocybin on mechanical hypersensitivity and thermal hyperalgesia in a rat model of formalin-induced chronic pain. Adult...

Leveraging psychedelic therapies for binge eating disorder

Open Access Government July 10, 2023 Jim Gilligan

Leveraging psychedelic therapies for binge eating disorder Here Tryp Therapeutics examine the viability of using psychedelic therapies for Binge Eating Disorder and the potential results that using psychedelic-assisted psychotherapy could have on different eating disorders. Tryp Therapeutics is a clinical-stage biotechnology company dedicated to the development of exclusive and innovative...