Attenuation of morphine withdrawal signs by intracerebral administration of 18-methoxycoronaridine.
European Journal of Pharmacology November 21, 2005 Vishal Panchal, Olga D Taraschenko, Isabelle M Maisonneuve et al. 30 citations
18-Methoxyroconaridine (18-MC), a synthetic derivative of ibogaine, reduces morphine self-administration and alleviates several signs of acute opioid withdrawal in rats. Although there is already well documented evidence of the mechanism mediating 18-MC's action to reduce the rewarding effects of morphine, nothing is known about the mechanism responsible for 18-MC's attenuation of opioid...