18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats.
European Journal of Pharmacology March 24, 2006 Stanley D Glick, Ruby L Ramirez, Jacklyn M Livi et al.
The novel iboga alkaloid congener 18-methoxycoronaridine (18-MC) is a putative anti-addictive agent that has been shown, in rats, to decrease the self-administration of morphine and other drugs of abuse. Previous work has established that 18-MC is a potent antagonist at alpha3beta4 nicotinic receptors. Because alpha3beta4 nicotinic receptors in the brain are preferentially located in the medial...
DOI: 10.1016/j.ejphar.2006.03.045 (opens in new tab)
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Ibogaine
Mesencephalon
Habenula
Animals
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