18-MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbens.
Synapse July 1, 2007 Olga D Taraschenko, Joseph M Shulan, Isabelle M Maisonneuve et al.
18-Methoxycoronaridine (18-MC), a novel iboga alkaloid congener, is a potential treatment for drug addiction. 18-MC has been shown to decrease self-administration of drugs (e.g., morphine, methamphetamine, nicotine) and attenuate opioid withdrawal in rats. In previous studies, systemic pretreatment with 18-MC abolished the sensitized increase in accumbens dopamine levels induced by chronic...
DOI: 10.1002/syn.20396 (opens in new tab)
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Ibogaine
Mesencephalon
Nucleus accumbens
Animals
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