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Gordana Koželj

4 papers in the library · 34 citations · publishing 2012-2021

Papers

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Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females.

Life (Basel, Switzerland) December 23, 2021 Nikola Tatalović, Teodora Vidonja Uzelac, Milica Mijović et al. 8 citations

Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males,...

Effects of ibogaine per os application on redox homeostasis in rat liver and erythrocytes

Archives of Biological Sciences December 5, 2018 Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al. 7 citations

Ibogaine, administered as a single oral dose (1-25 mg/kg body weight), has been used as an addiction-interrupting agent. Its effects persist for up to 72 h. Ex vivo results showed that ibogaine induced cellular energy consumption and restitution, followed by increased reactive oxygen species production and antioxidant activity. Therefore, the aim of this work was to explore the effect of a...

The syndrome of inappropriate antidiuretic hormone secretion after giant leaf frog (Phyllomedusa bicolor) venom exposure.

Toxicon : official journal of the International Society on Toxinology September 15, 2016 Vid Leban, Gordana Koželj, Miran Brvar

In Europe body purification and natural balance restoring rituals are becoming increasingly popular, but an introduction of Amazonian shamanic rituals in urban Europe can result in unexpected adverse events. A 44-year-old woman attended a Kambô or Sapo ritual in Slovenia where dried skin secretion from a giant leaf frog (Phyllomedusa bicolor) was applied to five freshly burned wounds at her...

Metabolic plasticity and the energy economizing effect of ibogaine, the principal alkaloid of Tabernanthe iboga.

Journal of Ethnopharmacology August 30, 2012 Roman Paškulin, Polona Jamnik, Tjaša Danevčič et al. 19 citations

The root bark of iboga plant-Tabernanthe iboga has been used traditionally in Central Africa as a psychoactive substance in religious rituals, while in smaller doses it is appreciated due to its stimulant properties. The iboga root bark, iboga extract or pure ibogaine are being recognized in the West as an anti-addiction remedy and their use is increasing. Our previous studies have demonstrated...