Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females.
Nikola Tatalović, Teodora Vidonja Uzelac, Milica Mijović, Gordana Koželj, Aleksandra Nikolić-kokić, Zorana Oreščanin-dušić, Mara Bresjanac, Duško Blagojević
Life (Basel, Switzerland) December 23, 2021 DOI: 10.3390/life12010016 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Female rats |
| Intervention | Ibogaine |
| Dose | 1 and 20 mg/kg b.w. per os |
| Duration | 6 and 24 hours after treatment |
| Topics | Ibogaine |
| Keywords | Erythrocytes Kidney Lipid peroxidation Liver Redox imbalance Ibogaine: ibogaine Compound Bioavailability Sex differences: sexes Female rats Sex-specific responses Protective thiols Catalase activity Altered xanthine oxidase Glycogen breakdown |
| Citations | 8 |
| Key points | Ibogaine's effects on antioxidant systems and glycogen metabolism in rats are sex-specific, with females showing lower liver glycogenolytic activity, higher thiol levels, and two to three times greater ibogaine bioavailability than males. |
Abstract
Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.