Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females.
Nikola Tatalović, Teodora Vidonja Uzelac, Milica Mijović, Gordana Koželj, Aleksandra Nikolić-kokić, Zorana Oreščanin-dušić, Mara Bresjanac, Duško Blagojević
Life December 23, 2021 DOI: 10.3390/life12010016 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Female rats |
| Intervention | Ibogaine |
| Dose | 1 and 20 mg/kg b.w. per os |
| Duration | 6 and 24 hours after treatment |
| Topics | Ibogaine |
| Keywords | Erythrocytes Kidney Lipid peroxidation Liver Redox imbalance Ibogaine: ibogaine Compound Bioavailability Sex differences: sexes Female rats Sex-specific responses Protective thiols Catalase activity Altered xanthine oxidase Glycogen breakdown |
| Citations | 8 |
| Key points | Ibogaine's effects on antioxidant systems and glycogen metabolism in rats are sex-specific, with females showing lower liver glycogenolytic activity, higher thiol levels, and two to three times greater ibogaine bioavailability than males. |
Abstract
Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.
Comparable studies
Other preclinical and animal studies on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine TE671/RD cells (human muscle-type nAChR) and SH-SY5Y neuroblastoma cells (human... | 1999 | In vitro study | |
| Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Ibogaine- or harmaline-treated rats | 1993 | Experimental animal study | |
| Effects and aftereffects of ibogaine on morphine self-administration in rats. Rats | 1991 | Preclinical experimental study | |
| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study |
Citations in the library
Cited by 5
- 5-HT2A Receptor Knockout Mice Show Sex-Dependent Differences following Acute Noribogaine Administration. International Journal of Molecular Sciences January 5, 2024
- Ibogaine Induces Cardiotoxic Necrosis in Rats-The Role of Redox Processes. International Journal of Molecular Sciences June 13, 2024
- A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets. Translational Psychiatry January 19, 2024
- Psychedelics for substance use disorders: are women being addressed? A scoping review International Journal of Drug Policy September 2, 2025
- Noribogaine altered intrinsic properties of thalamocortical neurons in a sex-dependent manner Progress in Neuro-Psychopharmacology and Biological Psychiatry August 1, 2025
Cites 20
- The ibogaine medical subculture. Journal of Ethnopharmacology January 4, 2008
- A preliminary investigation of ibogaine: case reports and recommendations for further study. Journal of Substance Abuse Treatment 1994
- Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures. Annals of the New York Academy of Sciences September 1, 2000
- Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration. European Journal of Pharmacology March 1, 2002
- Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependencea. Annals of the New York Academy of Sciences May 1, 1998
and 15 more in the library