Effects of ibogaine per os treatment on redox homeostasis in rat kidney
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović, Aleksandra Nikolić-kokić, Zorana Oreščanin-dušić, Mara Bresjanac, Duško Blagojević
Archives of Biological Sciences 2019 DOI: 10.2298/abs190208006v (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vivo animal study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Ibogaine |
| Dose | 1 or 20 mg/kg body weight |
| Duration | 6 and 24 h after administration |
| Topics | Ibogaine |
| Keywords | Oxidative stress Glutathione reductase Superoxide dismutase Pharmacology Glutathione peroxidase Tbars Catalase Antioxidant Kidney Biochemistry Endocrinology Enzyme Lipid peroxidation |
| Citations | 4 |
| Key points | Ibogaine altered kidney antioxidant enzyme activities and induced moderate morphological changes without measurably affecting kidney function in rats. |
Abstract
Our previous results showed that a single oral dose (1 or 20 mg/kg body weight) of the anti-addiction agent ibogaine induced in rats 6 and 24 h after administration glycogenolytic activity in hepatocytes, followed by a mild oxidative stress. In this work, we examined the in vivo effect of the same doses of ibogaine on rat kidney morphology, antioxidant enzyme (superoxide dismutases (SOD1 and 2), catalase, glutathione peroxidase, glutathione reductase (GR) and glutathione- S-transferase) activities, and oxidative stress (TBARS) and redox (-SH groups) parameters. The dose of 1 mg/kg ibogaine induced an elevation in SOD1 activity and decreased GR activity after 6 and 24 h. GR activity was decreased at 6 and 24 h after 20 mg/kg ibogaine administration, suggesting changed redox homeostasis. After 24 h, we observed an increase in moderate morphological changes, without changes in urinalyses, indicating that kidney function was not measurably affected. Nevertheless, kidney-function monitoring during and following ibogaine use in human subjects is advisable.
Comparable studies
Other preclinical and animal studies on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine TE671/RD cells (human muscle-type nAChR) and SH-SY5Y neuroblastoma cells (human... | 1999 | In vitro study | |
| Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Ibogaine- or harmaline-treated rats | 1993 | Experimental animal study | |
| Effects and aftereffects of ibogaine on morphine self-administration in rats. Rats | 1991 | Preclinical experimental study | |
| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study |
Citations in the library
Cited by 4
- Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females. Life December 23, 2021
- Ibogaine Induces Cardiotoxic Necrosis in Rats-The Role of Redox Processes. International Journal of Molecular Sciences June 13, 2024
- Ibogaine-Mediated ROS/Antioxidant Elevation in Isolated Rat Uterus Is β-Adrenergic Receptors and KATP Channels Mediated. Antioxidants (Basel, Switzerland) November 9, 2021
- Ex Vivo Effect of Ibogaine on the Transcriptional Level of Antioxidant Defense Related Genes in Honey Bee (Apis mellifera, L.) Midgut Brazilian Archives of Biology and Technology 2021
Cites 11
- The ibogaine medical subculture. Journal of Ethnopharmacology January 4, 2008
- A preliminary investigation of ibogaine: case reports and recommendations for further study. Journal of Substance Abuse Treatment 1994
- Influence of CYP2D6 activity on the pharmacokinetics and pharmacodynamics of a single 20 mg dose of ibogaine in healthy volunteers. The Journal of Clinical Pharmacology June 1, 2015
- Distribution of ibogaine and noribogaine in a man following a poisoning involving root bark of the Tabernanthe iboga shrub. Journal of Analytical Toxicology September 1, 2006
- Ibogaine affects brain energy metabolism. European Journal of Pharmacology December 15, 2006
and 6 more in the library