Effects of ibogaine per os treatment on redox homeostasis in rat kidney
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović, Aleksandra Nikolić-kokić, Zorana Oreščanin-dušić, Mara Bresjanac, Duško Blagojević
Archives of Biological Sciences 2019 DOI: 10.2298/abs190208006v (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vivo animal study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Ibogaine |
| Dose | 1 or 20 mg/kg body weight |
| Duration | 6 and 24 h after administration |
| Topics | Ibogaine |
| Keywords | Oxidative stress Glutathione reductase Superoxide dismutase Pharmacology Glutathione peroxidase Tbars Catalase Antioxidant Kidney Biochemistry Endocrinology Enzyme Lipid peroxidation |
| Citations | 4 |
| Key points | Ibogaine altered kidney antioxidant enzyme activities and induced moderate morphological changes without measurably affecting kidney function in rats. |
Abstract
Our previous results showed that a single oral dose (1 or 20 mg/kg body weight) of the anti-addiction agent ibogaine induced in rats 6 and 24 h after administration glycogenolytic activity in hepatocytes, followed by a mild oxidative stress. In this work, we examined the in vivo effect of the same doses of ibogaine on rat kidney morphology, antioxidant enzyme (superoxide dismutases (SOD1 and 2), catalase, glutathione peroxidase, glutathione reductase (GR) and glutathione- S-transferase) activities, and oxidative stress (TBARS) and redox (-SH groups) parameters. The dose of 1 mg/kg ibogaine induced an elevation in SOD1 activity and decreased GR activity after 6 and 24 h. GR activity was decreased at 6 and 24 h after 20 mg/kg ibogaine administration, suggesting changed redox homeostasis. After 24 h, we observed an increase in moderate morphological changes, without changes in urinalyses, indicating that kidney function was not measurably affected. Nevertheless, kidney-function monitoring during and following ibogaine use in human subjects is advisable.