Intrinsic excitation-inhibition imbalance in major depressive disorder.
Journal of Affective Disorders June 29, 2026 Yao Ge, Lijuan Chen, Yu Shen et al.
Major depressive disorder (MDD) ranks among the foremost contributors to disability worldwide, yet its neurophysiological mechanisms remain poorly understood. Excitation-inhibition (E/I) imbalance has been implicated in MDD pathophysiology, but cortex-wide E/I ratio and its molecular substrates in MDD remain unknown. Resting-state functional magnetic resonance imaging data from 254 MDD patients...