Major depressive disorder (MDD) ranks among the foremost contributors to disability worldwide, yet its neurophysiological mechanisms remain poorly understood. Excitation-inhibition (E/I) imbalance has been implicated in MDD pathophysiology, but cortex-wide E/I ratio and its molecular substrates in MDD remain unknown. Resting-state functional magnetic resonance imaging data from 254 MDD patients...
Meditation has been a spiritual and healing practice in the East for thousands of years. However, the neurophysiologic mechanisms underlying its traditional form remain unclear. In this study, we recruited a large sample of monks (n = 73) who practice Tibetan Buddhist meditation and compared with meditation-naive local controls (n = 30). Their electroencephalography (EEG) and electrocardiogram...
Meditation is a progressive process in which meditators may experience different stages to finally reach a deep meditation state. However, the temporal-dynamic process of meditation remains unclear. In this study, we recruited 38 experienced Tibetan Buddhism meditators to explore the dynamic process from resting to deep meditation from the aspects of EEG oscillations and networks. We found that...