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Mercè Pallàs

3 papers in the library · 2 citations · publishing 2004-2025

Papers

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Investigating the Synergistic Neuroprotective Effects of Plant-Derived Antioxidants and the Psychedelic N,N-Dimethyltryptamine in Alzheimer's Disease Therapy.

Cells June 19, 2025 Júlia Jarne-Ferrer, Mercè Pallàs, Christian Griñán-Ferré et al. 2 citations

Alzheimer's disease (AD) is a chronic and complex neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and irreversible impairment of brain functions. The etiology of AD is multifactorial, involving a complex interplay of genetic, environmental, and physiological factors, including the aggregation of amyloid-β (Aβ) and oxidative stress (OS). The role of OS in...

DOI: 10.3390/cells14120934 (opens in new tab) Full text (opens in new tab) N-dimethyltryptamine Alzheimer’s disease Oxidative stress Psychedelics +10

3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility.

Progress in Neuro-Psychopharmacology and Biological Psychiatry October 3, 2014 Sonia Abad, Fèlix Junyent, Carme Auladell et al.

Kainic acid (KA) causes seizures and neuronal loss in the hippocampus. The present study investigated whether a recreational schedule of 3,4-methylenedioxymethamphetamine (MDMA) favours the development of a seizure state in a model of KA-induced epilepsy and potentiates the toxicity profile of KA (20 or 30mg/kg). Adolescent male C57BL/6 mice received saline or MDMA t.i.d. (s.c. every 3h), on...

DOI: 10.1016/j.pnpbp.2014.06.007 (opens in new tab) Full text (opens in new tab) MDMA Calbindin Calretinin Kainic acid +2

Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells.

Toxicology and Applied Pharmacology April 15, 2004 Andrés Jiménez, Elvira G Jordà, Ester Verdaguer et al.

The neurotoxic action of the abuse drugs methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) on cerebellar granule neurones (CGNs) culture was examined. Treatment for 48 h with METH or MDMA (1-5 mM) induced a higher decrease in viability than 24 h treatment. z.VAD.fmk (100 microM) but not MK-801 nor NBQX recovered control viability values. In both cases, cell death was...

DOI: 10.1016/j.taap.2003.12.017 (opens in new tab) Full text (opens in new tab)