Jorge Camarasa

2 papers in the library · publishing 2014

Papers

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3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility.

Progress in Neuro-Psychopharmacology and Biological Psychiatry October 3, 2014 Sonia Abad, Fèlix Junyent, Carme Auladell et al.

Kainic acid (KA) causes seizures and neuronal loss in the hippocampus. The present study investigated whether a recreational schedule of 3,4-methylenedioxymethamphetamine (MDMA) favours the development of a seizure state in a model of KA-induced epilepsy and potentiates the toxicity profile of KA (20 or 30mg/kg). Adolescent male C57BL/6 mice received saline or MDMA t.i.d. (s.c. every 3h), on...

DOI: 10.1016/j.pnpbp.2014.06.007 Full text MDMA Calbindin Calretinin Kainic acid +2

Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies.

European journal of medicinal chemistry June 23, 2014 Salomé Llabrés, Sara Garcia-Ratés, Edgar Cristóbal-Lecina et al.

The α4β2 nicotinic acetylcholine receptor (nAChR) is a molecular target of 3,4-methylenedioxymethamphetamine (MDMA), a synthetic drug also known as ecstasy, and it modulates the MDMA-mediated reinforcing properties. However, the enantioselective preference of the α4β2 nAChR subtype still remains unknown. Since the two enantiomers exhibit different pharmacological profiles and stereoselective...

DOI: 10.1016/j.ejmech.2014.04.044 Full text MDMA Alpha4beta2 nicotinic receptor Enantioselective binding Molecular modelling +2