Carme Auladell

3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility.

Progress in Neuro-Psychopharmacology and Biological Psychiatry October 3, 2014 Sonia Abad, Fèlix Junyent, Carme Auladell et al.

Kainic acid (KA) causes seizures and neuronal loss in the hippocampus. The present study investigated whether a recreational schedule of 3,4-methylenedioxymethamphetamine (MDMA) favours the development of a seizure state in a model of KA-induced epilepsy and potentiates the toxicity profile of KA (20 or 30mg/kg). Adolescent male C57BL/6 mice received saline or MDMA t.i.d. (s.c. every 3h), on...