Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells.
Toxicology and Applied Pharmacology April 15, 2004 Andrés Jiménez, Elvira G Jordà, Ester Verdaguer et al.
The neurotoxic action of the abuse drugs methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) on cerebellar granule neurones (CGNs) culture was examined. Treatment for 48 h with METH or MDMA (1-5 mM) induced a higher decrease in viability than 24 h treatment. z.VAD.fmk (100 microM) but not MK-801 nor NBQX recovered control viability values. In both cases, cell death was...