Katrin H. Preller - The Consciousness Library

Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects.

Current Topics in Behavioral Neurosciences July 31, 2024 Nathalie M. Rieser, Timo T Schmidt, Katrin H. Preller 5 citations

This chapter offers a comprehensive overview of our current understanding of the neural mechanisms underlying the effects of psychedelic drugs, with a primary focus on human neuroimaging studies. Whenever possible, we explore the neurobiological mechanisms that may underly acute and subacute adverse effects and describe hypotheses on how these results may inform on the pathophysiology of...

DOI: 10.1007/7854_2024_507 Full text Neural mechanisms Neuroimaging Psychedelics

The influence of psilocybin on subconscious and conscious emotional learning

iScience May 19, 2024 Andres Ort, John W Smallridge, Erich Seifritz et al. 1 citation

Serotonergic psychedelics hold promise as a treatment modality for various psychiatric disorders and are currently applied in psychedelic-assisted psychotherapy. We investigated the learning effects of the serotonin receptor agonist psilocybin in a probabilistic cue-reward task with emotional cues in the form of neutral or fearful faces, presented either consciously or subconsciously. This...

DOI: 10.1016/j.isci.2024.110034 Psilocybin Subconscious Cognitive science

Effective Connectivity of Thalamocortical Interactions Following d-Amphetamine, LSD, and MDMA Administration.

Biological psychiatry. Cognitive neuroscience and neuroimaging May 1, 2024 Mihai Avram, Felix Müller, Katrin H. Preller et al. 13 citations

While the exploration of serotonergic psychedelics as psychiatric medicines deepens, so does the pressure to better understand how these compounds act on the brain. We used a double-blind, placebo-controlled, crossover design and administered lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA), and d-amphetamine in 25 healthy participants. By using spectral dynamic causal...

DOI: 10.1016/j.bpsc.2023.07.010 Full text LSD MDMA Dynamic causal modeling Effective connectivity +8

Ketamine induces multiple individually distinct whole-brain functional connectivity signatures.

Elife April 17, 2024 Flora Moujaes, Jie Lisa Ji, Masih Rahmati et al. 23 citations

Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine's molecular mechanisms connect to its neural and behavioral effects. We conducted a single-blind placebo-controlled study, with participants blinded to their treatment condition....

DOI: 10.7554/elife.84173 Full text Data reduction FMRI Gene expression Human +5

Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin

Biological Psychiatry January 5, 2024 Devon Stoliker, Leonardo Novelli, Adeel Razi et al. 42 citations

Our findings suggest that temporary amygdala signal attenuation is associated with mechanistic changes to resting-state network connectivity. These changes are significant for altered cognition and perception and suggest targets for research investigating the efficacy of psychedelic therapy for internalizing psychiatric disorders. More broadly, our study suggests the value of quantifying the...

DOI: 10.1016/j.biopsych.2024.01.002 Psilocybin Amygdala Cognition Resting State FMRI +3

Knowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms.

Neuroscience Applied 2024 Drummond E-Wen Mcculloch, Juan Pablo Lopez, Christina Dalla et al. 2 citations

Classical psychedelic drugs, e.g., psilocybin and LSD, stimulate the serotonin 2A receptor (5-HT2AR) and have recently been intensely investigated for their clinical effects in various brain disorders. At the ECNP "New Frontiers meeting" in March 2023, scientific experts in psychedelics met to identify key knowledge gaps in the mechanism of action of psychedelics as investigated using...

DOI: 10.1016/j.nsa.2023.103929 Full text Hallucinogen investigation Psychoactive drug research Entheogen research Psychedelic compounds +15

Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals

Neuroscience Applied December 30, 2023 Sophia Armand, Kristian Larsen, Martin K Madsen et al. 7 citations

The serotonergic psychedelic psilocybin acutely induces changes in emotional states. However, it remains unresolved whether psilocybin acutely modulates amygdala reactivity to emotions, a brain region critically involved in emotion processing. Using functional magnetic resonance imaging (fMRI), we examined in 26 healthy individuals whether amygdala responses to angry, fearful and neutral faces...

DOI: 10.1016/j.nsa.2023.103934 Psilocybin psychedelics Hallucinogens Emotional processing emotion Emotional regulation +10

Investigating functional brain connectivity patterns associated with two hypnotic states

Frontiers in Human Neuroscience December 19, 2023 Nuno M.p. de Matos, Philipp Staempfli, Erich Seifritz et al. 8 citations

While there's been clinical success and growing research interest in hypnosis, neurobiological underpinnings induced by hypnosis remain unclear. In this fMRI study (which is part of a larger hypnosis project) with 50 hypnosis-experienced participants, we analyzed neural and physiological responses during two hypnosis states, comparing them to non-hypnotic control conditions and to each other....

DOI: 10.3389/fnhum.2023.1286336 Hypnosis Voxel Planum temporale Functional connectivity +4

Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences.

Scientific Reports October 14, 2023 Nathalie M. Rieser, Ladina P Gubser, Flora Moujaes et al. 14 citations

Research into the use of psilocybin for the treatment of psychiatric disorders is a growing field. Nevertheless, robust brain-behavior relationships linking psilocybin-induced brain changes to subjective drug-induced effects have not been established. Furthermore, it is unclear if the acute neural effects are dependent on individual heterogeneity in baseline characteristics. To address this, we...

DOI: 10.1038/s41598-023-44153-z Full text Psychedelics Personalized medicine Brain imaging Mental health

Comparing Neural Correlates of Consciousness: From Psychedelics to Hypnosis and Meditation

Biological Psychiatry Cognitive Neuroscience and Neuroimaging July 17, 2023 Flora Moujaes, Nathalie M. Rieser, Christophe Phillips et al. 19 citations

BACKGROUND: Pharmacological and nonpharmacological methods of inducing altered states of consciousness (ASCs) are becoming increasingly relevant in the treatment of psychiatric disorders. While comparisons between them are often drawn, to date no study has directly compared their neural correlates. METHODS: To address this knowledge gap, we directly compared 2 pharmacological methods...

DOI: 10.1016/j.bpsc.2023.07.003 Psilocybin Meditation Default mode network Hypnosis +6

TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology.

iScience May 19, 2023 Andres Ort, John W Smallridge, Simone Sarasso et al. 47 citations

Exploring the neurobiology of the profound changes in consciousness induced by classical psychedelic drugs may require novel neuroimaging methods. Serotonergic psychedelic drugs such as psilocybin produce states of increased sensory-emotional awareness and arousal, accompanied by increased spontaneous electroencephalographic (EEG) signal diversity. By directly stimulating cortical tissue, the...

DOI: 10.1016/j.isci.2023.106589 Full text Psilocybin Medical imaging Pharmacology Neuroscience clinical neuroscience +6

Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial.

EClinicalMedicine February 1, 2023 Robin von Rotz, Eva M Schindowski, Johannes Jungwirth et al. 345 citations

Psilocybin has been suggested as a novel, rapid-acting treatment for depression. Two consecutive doses have been shown to markedly decrease symptom severity in an open-label setting or when compared to a waiting list group. To date, to our knowledge, no other trial compared a single, moderate dose of psilocybin to a placebo condition. In this double-blind, randomised clinical trial, 52...

DOI: 10.1016/j.eclinm.2022.101809 Full text Depression Major depressive disorder Psychedelic-assisted therapy Magic mushrooms +8

Effective Connectivity of Functionally Anticorrelated Networks Under Lysergic Acid Diethylamide.

Biological Psychiatry February 1, 2023 Devon Stoliker, Leonardo Novelli, Franz X. Vollenweider et al. 49 citations

Classic psychedelic-induced ego dissolution involves a shift in the sense of self and a blurring of the boundary between the self and the world. A similar phenomenon is identified in psychopathology and is associated with the balance of anticorrelated activity between the default mode network, which directs attention inward, and the salience network, which recruits the dorsal attention network...

DOI: 10.1016/j.biopsych.2022.07.013 Full text Ego dissolution Anticorrelated networks Dynamic causal modeling Effective connectivity +8

Corrigendum to 'Single-dose psilocybin-assisted therapy in major depressive disorder: a placebo-controlled, double-blind, randomised clinical trial'.

EClinicalMedicine February 1, 2023 Robin von Rotz, Eva M Schindowski, Johannes Jungwirth et al. 8 citations correction

We wish to provide a correction of the colour representation of Fig. 2 in order to harmonise the colours representing the Psilocybin and the Placebo condition with the corresponding figure caption and with the colour codes from all other figures across the manuscript. Fig. 2 now depicts the Psilocybin condition in blue and the Placebo condition in yellow. The error occurred as a result of an...

DOI: 10.1016/j.eclinm.2023.101841 Full text Psilocybin Depression Correction Clinical trials +1

Toward Mapping Neurobehavioral Heterogeneity of Psychedelic Neurobiology in Humans

Biological Psychiatry December 7, 2022 Flora Moujaes, Katrin H. Preller, Jie Lisa Ji et al. 44 citations

Precision psychiatry aims to identify markers of interindividual variability that allow for predicting the right treatment for each patient. However, bridging the gap between molecular-level manipulations and neural systems-level functional alterations remains an unsolved problem in psychiatry. After decades of low success rates in pharmaceutical research and development for psychiatric drugs,...

DOI: 10.1016/j.biopsych.2022.10.021 Full text

The neural basis of psychedelic action.

Nat Neurosci October 24, 2022 Alex C. Kwan, David E. Olson, Katrin H. Preller et al. 291 citations

Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in perception, cognition and mood. In this review, we focus on the basic neurobiology underlying the action of psychedelic drugs. We first discuss chemistry, highlighting the diversity of psychoactive molecules and the principles that govern their potency and pharmacokinetics. We describe the roles of serotonin...

DOI: 10.1038/s41593-022-01177-4 Full text

Effective connectivity of emotion and cognition under psilocybin

medRxiv September 9, 2022 Devon Stoliker, Leonardo Novelli, Franz X. Vollenweider et al. 4 citations preprint

Abstract Classic psychedelics alter sense of self and patterns of self-related thought. These changes are hypothesised to underlie their therapeutic efficacy across internalising pathologies such as addiction and depression. Using resting-state functional MRI images from a randomised, double blinded, placebo-controlled clinical trial of 24 healthy adults under 0.215mg/kg psilocybin, we...

DOI: 10.1101/2022.09.06.22279626 Full text Psilocybin Default mode network Amygdala Hallucinogen +3

Editorial: Psychedelic sociality: Pharmacological and extrapharmacological perspectives

Frontiers in Pharmacology July 22, 2022 Leor Roseman, Katrin H. Preller, Evgenia Fotiou et al. 15 citations

The heralded psychedelic renaissance is currently at a new level where psychedelics are being accepted by the scientific community and the public. Medicalization and the ongoing introduction of market forces are imposing a trend in which psychedelic treatments are reduced to focus into strictly pharmacological and psychological effects on the self, rather than interactions with broader social...

DOI: 10.3389/fphar.2022.979764 Neuropharmacology Sociality

Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses.

Neuroscience and Biobehavioral Reviews July 1, 2022 Drummond E-Wen Mcculloch, Gitte Moos Knudsen, Frederick Streeter Barrett et al. 14 citations

Clinical research into serotonergic psychedelics is expanding rapidly, showing promising efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI) is a commonly used strategy to identify psychedelic-induced changes in neural pathways in clinical and healthy populations. Here we, a large group of psychedelic imaging researchers, review the 42 research...

DOI: 10.1016/j.neubiorev.2022.104689 Full text DMT LSD Psilocin Psilocybin +10

A neurobiological perspective on social influence: Serotonin and social adaptation

Journal of Neurochemistry March 11, 2022 Patricia Duerler, Franz X. Vollenweider, Katrin H. Preller 50 citations

Abstract Humans are inherently social beings. Being suggestible to each other's expectations enables pro‐social skills that are crucial for social learning and adaptation. Despite their high relevance for psychiatry, the neurobiological mechanisms underlying social adaptation are still not well understood. This review, therefore, provides a conceptual framework covering various distinct...

DOI: 10.1111/jnc.15607 Serotonin Perspective graphical Adaptation eye Cognitive psychology +1

Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD

Elife July 12, 2021 Joshua B. Burt, Katrin H. Preller, Murat Demirtaş et al. 49 citations

Psychoactive drugs can transiently perturb brain physiology while preserving brain structure. The role of physiological state in shaping neural function can therefore be investigated through neuroimaging of pharmacologically induced effects. Previously, using pharmacological neuroimaging, we found that neural and experiential effects of lysergic acid diethylamide (LSD) are attributable to...

DOI: 10.7554/elife.69320 Lysergic acid diethylamide Serotonin Mechanism biology Biological neural network +6

Psilocybin Induces Aberrant Prediction Error Processing of Tactile Mismatch Responses—A Simultaneous EEG–FMRI Study

Cerebral Cortex June 10, 2021 Patricia Duerler, Silvia Brem, Gorka Fraga González et al. 64 citations

Abstract As source of sensory information, the body provides a sense of agency and self/non-self-discrimination. The integration of bodily states and sensory inputs with prior beliefs has been linked to the generation of bodily self-consciousness. The ability to detect surprising tactile stimuli is essential for the survival of an organism and for the formation of mental body representations....

DOI: 10.1093/cercor/bhab202 Full text Psilocybin Electroencephalography EEG-FMRI Audiology +4

LSD and ketanserin and their impact on the human autonomic nervous system

Psychophysiology March 27, 2021 Sebastian Olbrich, Katrin H. Preller, Franz X. Vollenweider 34 citations

Abstract The interest in lysergic acid diethylamide (LSD) has sparked again due to its supposed positive effects on psychopathological conditions. Yet, most research focuses on the actions of LSD on the central nervous system. The interaction with the autonomic nervous system (ANS) has been neglected so far. Therefore, the aim was to assess the effects of LSD and the serotonin 2A receptor...

DOI: 10.1111/psyp.13822 Ketanserin Placebo Autonomic nervous system Analysis of variance +6

Classical Psychedelics as Therapeutics in Psychiatry – Current Clinical Evidence and Potential Therapeutic Mechanisms in Substance Use and Mood Disorders

Pharmacopsychiatry January 20, 2021 Lea J. Mertens, Katrin H. Preller 63 citations

Abstract Classical psychedelics, primarily psilocybin and lysergic acid diethylamide (LSD), have been used and extensively studied in Western medicine as part of substance-assisted psychotherapy in the 1950s and 1960s. Modern clinical research is currently gaining momentum and provides new evidence for the safety and efficacy of classical psychedelics (primarily psilocybin, but also LSD and...

DOI: 10.1055/a-1341-1907 Psilocybin Lysergic acid diethylamide Hallucinogen Clinical trial +3

Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine

Journal of Neuroscience November 30, 2020 Danilo de Gregorio, Argel Aguilar-Valles, Katrin H. Preller et al. 258 citations

A revamped interest in the study of hallucinogens has recently emerged, especially with regard to their potential application in the treatment of psychiatric disorders. In the last decade, a plethora of preclinical and clinical studies have confirmed the efficacy of ketamine in the treatment of depression. More recently, emerging evidence has pointed out the potential therapeutic properties of...

DOI: 10.1523/jneurosci.1659-20.2020 Full text Psilocybin MDMA Mescaline Ketamine +2

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