EXCLI journal
2026
Chun-Hua Xu, Bi-Lan Zhang, Chun-Lan Guan et al.
Mindfulness-based cognitive therapy (MBCT) demonstrates significant efficacy in improving depressive symptoms and modulating metabolic profiles. However, the specific metabolite biomarkers and metabolic pathways underlying MBCT's therapeutic effects in adolescent depression remain unclear. This study aims to identify potential metabolite biomarkers and metabolic regulation pathways associated...
Frontiers in Neuroscience
2025
Zuxing Feng, Yanli Li, Ying Cai et al.
2 citations
Retracted
With the use of ketamine, Glutamate (Glu) system has gradually become the focus of antidepressant effects. N-methyl-D-aspartate receptor (NMDAR), as one of the major ionic glutamate receptors, plays a dominant role in antidepressant effects, especially in synaptic plasticity. Few studies have been conducted on changes of NMDAR-related indicators and inflammatory cytokines in major depressive...
Journal of experimental psychology. General
February 1, 2023
Mengdi Huang, Fan Yang
38 citations
We all desire to have meaningful experiences in life, but what factors give rise to perceptions of meaning? Across seven preregistered studies (total N = 1362), we examined the role of self-transcendence (i.e., benefits to society) and self-enhancement (i.e., benefits to the self) in people's judgments of meaning, in comparison with their judgments of happiness. We found that people weighed...
Cognition & Emotion
February 1, 2023
Yena Kim, Howard C Nusbaum, Fan Yang
22 citations
Having good moral character often involves shifting one's focus of attention from the self to others and the world. Across three studies (N = 605 adults), we found converging evidence that self-transcendent experiences, specifically awe and flow, enabled the expression of wisdom, as captured by wise reasoning and epistemic humility measures. Study 1 found that dispositionally awe- and...
Frontiers in Psychology
2023
Brian H. Ge, Fan Yang
30 citations
Suffering is inevitable in human life. Our perspective paper theorizes on precise mechanisms for how self-transcendence-the state in which an individual looks beyond the self and adopts a larger perspective including concern for others and the world-may help people endure the experience of suffering. From an examination of empirical literature ranging from social psychology to clinical...