Psychological Medicine
September 1, 2023
Shaked E. Leibovitz, Gunes Sevinc, Jonathan Greenberg et al.
3 citations
Abstract Background The ability to extinguish a maladaptive conditioned fear response is crucial for healthy emotional processing and resiliency to aversive experiences. Therefore, enhancing fear extinction learning has immense potential emotional and health benefits. Mindfulness training enhances both fear conditioning and recall of extinguished fear; however, its effects on fear extinction...
Brain and Behavior
September 18, 2020
Gunes Sevinc, Jonathan Greenberg, Britta K. Hölzel et al.
24 citations
Abstract Introduction Mindfulness meditation has successfully been applied to cultivate skills in self‐regulation of emotion, as it employs the unbiased present moment awareness of experience. This heightened attention to and awareness of sensory experience has been postulated to create an optimal therapeutic exposure condition and thereby improve extinction learning. We recently demonstrated...
Biological Psychiatry
May 30, 2019
Gunes Sevinc, Britta K. Hölzel, Jonathan Greenberg et al.
Background: The role of hippocampus in context-dependent recall of extinction is well recognized. However, little is known about how intervention-induced changes in hippocampal networks relate to improvements in extinction learning. In this study, we hypothesized that mindfulness training creates an optimal exposure condition by heightening attention and awareness of present moment sensory...
Frontiers in Psychiatry
2018
Sean D Conrin, Liang Zhan, Zachery D Morrissey et al.
Connectomics is a framework that models brain structure and function interconnectivity as a network, rather than narrowly focusing on select regions-of-interest. MRI-derived connectomes can be structural, usually based on diffusion-weighted MR imaging, or functional, usually formed by examining fMRI blood-oxygen-level-dependent (BOLD) signal correlations. Recently, we developed a novel method...
Frontiers in Behavioral Neuroscience
2016
Britta K. Hölzel, Vincent Brunsch, Tim Gard et al.
Mindfulness has been suggested to impact emotional learning, but research on these processes is scarce. The classical fear conditioning/extinction/extinction retention paradigm is a well-known method for assessing emotional learning. The present study tested the impact of mindfulness training on fear conditioning and extinction memory and further investigated whether changes in white matter...
Neurobiology of Learning and Memory
September 2014
Christine A Rabinak, Mike Angstadt, Maryssa Lyons et al.
Pre-extinction administration of Δ9-tetrahydrocannibinol (THC) facilitates recall of extinction in healthy humans, and evidence from animal studies suggest that this likely occurs via enhancement of the cannabinoid system within the ventromedial prefrontal cortex (vmPFC) and hippocampus (HIPP), brain structures critical to fear extinction. However, the effect of cannabinoids on the underlying...