Effect of esketamine on the ED50 of propofol for successful insertion of ureteroscope in elderly male patients: a randomized controlled trial.
BMC Anesthesiology May 31, 2024 Xin Luo, Wen-Wen Hao, Xue Zhang et al. 7 citations
Adding esketamine to propofol reduces the amount of propofol needed for successful ureteroscope insertion in elderly male patients compared with adding sufentanil. In a randomized trial of 49 elderly men undergoing rigid ureteroscopy, the median effective dose (ED50) of propofol was 1.356 mg/kg with esketamine versus 1.442 mg/kg with sufentanil, a statistically significant decrease. Induction time was also shorter with esketamine, and hemodynamic stability was better. Rates of adverse events such as hypoxemia and body movement did not differ between groups. The combination may improve safety by lowering propofol requirements in this older population.