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Bienose S Chijioke

2 papers in the library · publishing 2026

Papers

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Syringic Acid Prevents and Reverses Ketamine-induced Schizophrenia-like Memory Impairment

Pharmacology and Toxicology of Natural Medicines October 31, 2026 Benneth Ben-Azu, Joseph O.T Emudainohwo, Bienose S Chijioke et al.

Background and Purpose: Alterations in the cholinergic-inflammatory pathway are believed to play a role in the cognitive symptoms of schizophrenia, a common neuropsychiatric condition characterised by altered perceptions of reality and impairments in learning and memory. In this study, we examined the preventive and reversal effects of syringic acid (SA), a naturally occurring phenolic...

Sabinene's neuroprotective effect reverses ketamine-induced experimental schizophrenia in mice through enhancement of cholinergic, antioxidant, and anti-inflammatory mechanisms.

Journal of Psychiatric Research March 5, 2026 Lydia Ben-Azu, Onyeka B Onyeukwu, Bienose S Chijioke et al.

Schizophrenia is a serious neuropsychiatric disorder marked by oxidative stress, immune system changes, and neurochemical imbalances. Current treatments are constrained by inconsistent effectiveness and side effects. This study evaluates the neuroprotective effects of sabinene, a monoterpene, in a mouse model of ketamine-induced schizophrenia. Male mice received ketamine (20 mg/kg/day, i.p.)...

DOI: 10.1016/j.jpsychires.2026.02.055 (opens in new tab) Ketamine Hippocampus Prefrontal cortex Animals +13