Sabinene's neuroprotective effect reverses ketamine-induced experimental schizophrenia in mice through enhancement of cholinergic, antioxidant, and anti-inflammatory mechanisms.
Journal of Psychiatric Research March 5, 2026 Lydia Ben-Azu, Onyeka B Onyeukwu, Bienose S Chijioke et al.
Schizophrenia is a serious neuropsychiatric disorder marked by oxidative stress, immune system changes, and neurochemical imbalances. Current treatments are constrained by inconsistent effectiveness and side effects. This study evaluates the neuroprotective effects of sabinene, a monoterpene, in a mouse model of ketamine-induced schizophrenia. Male mice received ketamine (20 mg/kg/day, i.p.)...
DOI: 10.1016/j.jpsychires.2026.02.055 (opens in new tab)
Ketamine
Hippocampus
Prefrontal cortex
Animals
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