Background and Purpose: Alterations in the cholinergic-inflammatory pathway are believed to play a role in the cognitive symptoms of schizophrenia, a common neuropsychiatric condition characterised by altered perceptions of reality and impairments in learning and memory. In this study, we examined the preventive and reversal effects of syringic acid (SA), a naturally occurring phenolic...
Background: Jobelyn® (JB) is a polyherbal formulation with proven benefits on psychosis, a psychiatric disorder, validated in dopamine-agonist models. However, its effect in ketamine, a glutamate antagonist, is linked to schizophrenia's pathology due to N-methyl-D-aspartate (NMDA) receptor hypofunction, which remains largely unknown. Hence, this study investigates the antipsychotic effectsof JB...
A decrease in the levels of antioxidant arsenals exacerbate generation of reactive oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on the pathogenesis of psychotic disorders such as schizophrenia. This study examined the preventive and reversal effects of diosgenin, a phyto-steroidal saponin with antioxidant functions in mice treated with ketamine which...