Background: Jobelyn® (JB) is a polyherbal formulation with proven benefits on psychosis, a psychiatric disorder, validated in dopamine-agonist models. However, its effect in ketamine, a glutamate antagonist, is linked to schizophrenia's pathology due to N-methyl-D-aspartate (NMDA) receptor hypofunction, which remains largely unknown. Hence, this study investigates the antipsychotic effectsof JB...
Background and Purpose: Schizophrenia is a chronic, debilitating psychiatric disorder affecting many young adult populations worldwide. Evidence from studies of central changes in the oxidative defense system suggests the involvement of oxidative stress in the pathophysiology of schizophrenia. Jobelyn® (JB) is a commercial polyherbal formulation that has been documented to show beneficial...
Schizophrenia is a serious neuropsychiatric disorder marked by oxidative stress, immune system changes, and neurochemical imbalances. Current treatments are constrained by inconsistent effectiveness and side effects. This study evaluates the neuroprotective effects of sabinene, a monoterpene, in a mouse model of ketamine-induced schizophrenia. Male mice received ketamine (20 mg/kg/day, i.p.)...