Effect of intraoperative low-dose esketamine on postoperative quality of recovery in patients undergoing laparotomy for gynecologic malignancy: a randomized controlled trial
Zhi-Yu Geng, Yan Zhang, Hui Bi, Xin Yan, Linlin Song, Hui-Cheng Song
International Journal of Surgery September 23, 2025 DOI: 10.1097/js9.0000000000003501 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Patients undergoing gynecologic malignancy laparotomy |
| Intervention | Esketamine |
| Dose | low-dose |
| Topics | Ketamine Esketamine |
| Keywords | Laparotomy Randomized controlled trial Anesthesia Surgery Gynecologic oncology Gynecologic surgical procedures Analgesic Postoperative pain Patient-controlled analgesia |
| Citations | 1 |
| Post-publication review | 1 comment on PubPeer (opens in new tab) · last active October 2025 |
| Key findings | Intraoperative low-dose esketamine failed to further improve the QoR-40 score after gynecologic malignancy laparotomy when used as part of a multimodal analgesic regimen. |
Abstract
Intraoperative low-dose esketamine failed to further improve the QoR-40 score after gynecologic malignancy laparotomy when used as part of a multimodal analgesic regimen. Further research is needed to explore the optimal dosage and indications of esketamine in this patient population.