G. Lewis

2 papers in the library · publishing 2015-2022

Papers

The development and internal evaluation of a predictive model to identify for whom Mindfulness-Based Cognitive Therapy (MBCT) offers superior relapse prevention for recurrent depression versus maintenance antidepressant medication

Clinical psychological science : a journal of the Association for Psychological Science April 29, 2022 Z. Cohen, R. DeRubeis, Rachel Hayes et al.

Depression often returns even after successful treatment. Using data from 424 adults with recurrent depression, researchers built models to predict relapse over 24 months for those continuing antidepressant medication (ADM) versus switching to mindfulness-based cognitive therapy (MBCT). Only the ADM model modestly predicted relapse better than baseline severity. People with the poorest ADM prognosis who switched to MBCT had lower relapse rates (48% vs. 70%) and longer time before relapse than those who stayed on ADM. For those with moderate or good ADM prognosis, both treatments led to similar relapse likelihood. The results suggest predictive models could help tailor relapse prevention choices.

DOI: 10.1177/21677026221076832 Full text Medicine Psychology

Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial

The Lancet July 4, 2015 W. Kuyken, Rachel Hayes, B. Barrett et al.

For people with a history of recurrent depression, mindfulness-based cognitive therapy combined with support to taper antidepressants is not superior to continuing maintenance antidepressants for preventing relapse over two years. In a randomized trial of 424 adults with three or more prior episodes, the time to relapse did not differ between the two groups. Both treatments were associated with enduring positive outcomes in terms of relapse, residual symptoms, and quality of life. Serious adverse events were rare and similar across groups. The findings suggest that MBCT with tapering support offers a comparable alternative to long-term antidepressant use.

DOI: 10.1016/s0140-6736(14)62222-4 Full text Medicine Psychology