BJPsych Open
July 1, 2026
Chloe Hambly Lapointe, Lilith Nosko, C. Crocker et al.
Background Recently, there has been a significant rise in potency (% tetrahydrocannabinol (THC)) of cannabis products globally. As such, there is a need for a better understanding of the relationship between cannabis potency and mental health outcomes, especially in a developmentally vulnerable population such as adolescents and young adults. Aims The objective of this scoping review was to...
JAMA Psychiatry
April 9, 2025
Jessica Ahrens, Sabrina D. Ford, Betsy Schaefer et al.
This cohort study investigates the association between cannabis and the midbrain dopamine pathway involved in psychosis.
EClinicalMedicine
September 8, 2023
Mathilde Argote, Guillaume Sescousse, Jérôme Brunelin et al.
31 citations
Background: The association between cannabis use and positive symptoms in schizophrenia spectrum disorders is well documented, especially via meta-analyses. Yet, findings are inconsistent regarding negative symptoms, while other dimensions such as disorganization, depression, and excitement, have not been investigated. In addition, meta-analyses use aggregated data discarding important...
Journal of dual diagnosis
July 3, 2023
Benedikt Fischer, W. Hall, T. Fidalgo et al.
Abstract Objective: Cannabis use is increasingly normalized; psychosis is a major adverse health outcome. We reviewed evidence on cannabis use-related risk factors for psychosis outcomes at different stages toward recommendations for risk reduction by individuals involved in cannabis use. Methods: We searched primary databases for pertinent literature/data 2016 onward, principally relying on...
Brain and Behavior
October 6, 2017
Rohit Jaibhagwan Lodhi, Yabing Wang, David Rossolatos et al.
12 citations
Abstract Objective COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample. Methods One hundred and sixty‐nine subjects with psychosis were recruited. AoP, defined as age of DSM‐IV diagnosis was established using the...
Jessica Ahrens, Sabrina D. Ford, Betsy Schaefer et al.
preprint
Abstract Importance Despite evidence that individuals who use cannabis early in life are at elevated risk of psychosis and that the neurotransmitter dopamine has a role in both conditions, the mechanism linking the two conditions remains unclear. Objective To use neuromelanin-sensitive MRI (neuromelanin-MRI), a practical, proxy measure of dopamine function, to assess whether a common alteration...